From Angstroms to Nanometers: Measuring Interatomic Distances by Solid-State NMR
Year: 2021
Type: review
Abstract: Internuclear distances represent one of the main structural constraints in molecular structure determination using solid-state NMR spectroscopy, complementing chemical shifts and orientational restraints. Although a large number of magic-angle-spinning (MAS) NMR techniques have been available for distance measurements, traditional 13 C and 15 N NMR experiments are inherently limited to distances of a few angstroms due to the low gyromagnetic ratios of these nuclei. Recent development of fast MAS triple-resonance 19 F and 1 H NMR probes has stimulated the design of MAS NMR experiments that measure distances in the 1–2 nm range with high sensitivity. This review describes the principles and applications of these multiplexed multidimensional correlation distance NMR experiments, with an emphasis on 19 F- and 1 H-based distance experiments. Representative applications of these long-distance NMR methods to biological macromolecules as well as small molecules are reviewed.
Source: Chemical Reviews
Institution: Massachusetts Institute of Technology
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Awards: G2153353313, G2950671353, Structures and Dynamics of Proton and Cation-Dependent Channels and Transporters, Structures and lipid interactions of curvature-inducing membrane peptides by NMR, G4305611965, G4524128745, MIT/Harvard Center for Magnetic Resonance, Solid-state NMR studies of the dynamic interactions of the influenza A M2 membrane protein with water, antiviral drugs, and the M1 protein
OpenAlex ID: W3211109069