Work

Author response: Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

Year: 2021

Type: peer-review

Abstract: Striatal cholinergic interneurons and astrocytes lose cilia and show dysregulation of Hedgehog signaling in mice with a Parkinson's disease-associated, G2019S LRRK2 mutation or upon loss of PPM1H phosphatase specific for LRRK2-phosphorylated Rab GTPases.

Source: eLife

DOI: 10.7554/elife.67900.sa2

Authors: Shahzad S Khan, Yuriko Sobu, Herschel S Dhekne, Francesca Tonelli, Kerryn Berndsen, Dario R Alessi, Suzanne R Pfeffer

Institutions: Stanford Medicine, Aligning Science Across Parkinson's, Stanford University, University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

OpenAlex ID: W3211141592

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