Work

A biomimetic S H 2 cross-coupling mechanism for quaternary sp 3 -carbon formation

Year: 2021

Type: article

Abstract: Radical substitution Nucleophilic substitution is a venerable reaction in organic chemistry. Typically, an incoming ion delivers two electrons to a carbon center while a departing ion takes two electrons away with it. The one-electron analog, homolytic substitution, is more rarely used, in part because the incoming neutral radicals can self-couple instead of bonding to the intended target. Liu et al . report that an iron porphyrin catalyst can direct homolytic substitution between primary and tertiary carbon radicals by selectively activating the primary partners. —JSY

Source: Science

DOI: 10.1126/science.abl4322

Authors: Wei Liu, Marissa N. Lavagnino, Colin A. Gould, Jesús Alcázar, David W. C. MacMillan

Institution: Princeton University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Photoredox Catalysis Applications in Organometallics and Chemical Biology