miR-506-3p can inhibit cell proliferation and is a diagnostic and prognostic marker of liver cancer.
Year: 2021
Type: article
Study design: Observational Study
Abstract: BACKGROUND: At the time of diagnosis, most patients with liver cancer (LC) are at advanced stage, which increases the difficulty of treatment. MiR-506-3p is considered an anti-oncogene in a wide spectrum of malignancies. This investigation aims to determine the clinical implications of miR-506-3p in diagnosis and prognosis of LC. METHODS: The expression of miR-506-3p in tissues and serum samples of 92 LC patients was detected using quantitative real-time PCR (qRT-PCR), and the connection between serum miR-506-3p and pathologic features of LC patients was analyzed. The diagnostic efficacy of miR-506-3p in LC was visualized by Receiver Operating Characteristic (ROC) curves, its prognostic implications in LC were confirmed by follow-up, and its impact on LC cell proliferation was analyzed by CCK-8 assay. RESULTS: experiments identified that the proliferation of LC cells decreased significantly following miR-506-3p up-regulation. CONCLUSION: miR-506-3p, capable of inhibiting LC cell proliferation, is a possible diagnostic and prognostic biomarker of LC.
Source: PubMed
Authors: Hongyan Xu, Ming Luo, Huali Xiang, Wenjun Liao, Hui Huang, Yan Wu, Jinhong Mei
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3211462088