Missing diagnoses of congenital cytomegalovirus infection in electronic health records for infants with laboratory-confirmed infection
Year: 2021
Type: article
Study design: Observational Study
Abstract: Congenital cytomegalovirus (CMV) is a leading cause of non-genetic sensorineural hearing loss and neurodevelopmental disabilities among US children. Studies using administrative healthcare databases have identified infants with congenital CMV using diagnostic codes from the International Classification of Diseases, Ninth and Tenth Revision, Clinical Modification. Using Cerner Health Facts deidentified electronic health records, we assessed the sensitivity of CMV diagnostic codes among infants with laboratory confirmed congenital CMV infection (i.e. a positive CMV laboratory test - polymerase chain reaction, direct fluorescent antibody, or culture from urine, saliva, respiratory secretion or blood samples, or IgM serology - within 21 days of life). During 2010-2017, 668 congenital CMV cases were identified among 7,517,207 infants with encounters within 21 days of life, or 0.89 cases per 10,000 infants. The sensitivity of CMV diagnostic codes assigned within 21 and 90 days of life was 10.3% (95% CI: 8.2-12.9) and 11.1% (95% CI: 8.9-13.7), respectively.
Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, National Center on Birth Defects and Developmental Disabilities, National Institutes of Health Clinical Center
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: National Institutes of Health
Award: G7543494365
OpenAlex ID: W3211635019