Studies examining mast cells, nanomaterials, and immunoglobulins to treat breast cancer, atherosclerosis, and allergies
Year: 2019
Type: article
Abstract: Mast cells (MC) are important immune sentinels found in most tissue and widely recognized for their role as mediators of Type I hypersensitivity. However, they also secrete anti-cancer mediators such as tumor necrosis factor alpha (TNF-a) and granulocyte-macrophage colony-stimulating factor (GM-CSF). In addition, MC and their secreted cytokines play a role in the development of atherosclerotic plaque and allergic reactions. Herein, it is demonstrated that MC differentiated from adipose derived stem cells, target and induce breast cancer cell apoptosis via an IgE-mediated targeting method. It also demonstrated that the fullerene derivatives (FDs) inhibit atherosclerotic plaque formation by reducing MC cytokine release. Finally, the demonstration of a low-affinity anti-IgE antibody, that binds to and desensitizes MC, can be used for allergy therapy is exhibited herein. [This abstract has been edited to remove characters that will not display in this system. Please see the PDF for the full abstract.]
Author: Michael Elias
Language: English
Topic: Mast cells and histamine
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3211636941