Work

Epigenetic condensates regulate chromatin activity and tumorigenesis

Year: 2021

Type: editorial

Abstract: Alterations of epigenetic modulators are extensively associated with cancer, but their key molecular activities in cancer regulation are often unclear. We discovered that lysine demethylase 6A (KDM6A, also known as UTX) suppresses cancer by forming liquid-like condensates with lysine methyltransferase 2D (KMT2D, also known as MLL4) and regulating chromatin activity at multiple levels.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2021.1997040

Authors: Bi Shi, Wei Li, Hao Jiang

Institutions: University of Virginia Cancer Center, University of Virginia

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,590