Translational Aspects of the Immunology of Clostridioides difficile Infection: Implications for Pediatric Populations
Year: 2021
Type: review
Abstract: Clostridioides difficile has become the most common healthcare-associated pathogen in the United States, leading the US Centers for Disease Control and Prevention (CDC) to classify C. difficile as an "urgent" public health threat that requires "urgent and aggressive action." This call to action has led to new discoveries that have advanced our understanding of Clostridioides difficile infection (CDI) immunology and clinical development of immunologic-based therapies for CDI prevention. However, CDI immunology research has been limited in pediatric populations, and several unanswered questions remain regarding the function of host immune response in pediatric CDI pathogenesis and the potential role of immunologic-based therapies in children. This review summarizes the innate and adaptive immune responses previously characterized in animals and humans and provides a current update on clinical development of immunologic-based therapies for CDI prevention in adults and children. These data inform the future research needs for children.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1055630737, G2002131387, G2632787645, Molecular interactions in the gut microbiota during early life colonization and perturbation, G4576017288, The Impact of Vancomycin-Resistant Entercoccus on Clostridium difficile Infection, Decoding Antibiotic-induced Susceptibility to Clostridium difficile Infection, Identifying the Breadth of Antibody Responses to Clostridioides difficile Infection, Dynamics of Colonization and Infection by Multidrug-resistant Pathogens in Immunocompromised and Critically Ill Patients (DYNAMITE)
OpenAlex ID: W3212710684