Year: 2020
Type: article
Abstract: OBJECTIVE: To determine changes in the incidence of dementia between 1988 and 2015. METHODS: This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from the Alzheimer Cohort Consortium. First, we calculated age- and sex-specific incidence rates for all-cause dementia, and then defined nonoverlapping 5-year epochs within each study to determine trends in incidence. Estimates of change per 10-year interval were pooled and results are presented combined and stratified by sex. RESULTS: Of 49,202 individuals, 4,253 (8.6%) developed dementia. The incidence rate of dementia increased with age, similarly for women and men, ranging from about 4 per 1,000 person-years in individuals aged 65-69 years to 65 per 1,000 person-years for those aged 85-89 years. The incidence rate of dementia declined by 13% per calendar decade (95% confidence interval [CI], 7%-19%), consistently across studies, and somewhat more pronouncedly in men than in women (24% [95% CI 14%-32%] vs 8% [0%-15%]). CONCLUSION: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies. Incidence is similar for men and women, although declines were somewhat more profound in men. These observations call for sustained efforts to finding the causes for this decline, as well as determining their validity in geographically and ethnically diverse populations.
Source: Neurology
Authors: Frank J. Wolters, Lori B. Chibnik, Reem Waziry, Roy Anderson, Claudine Berr, Alexa Beiser, Joshua C. Bis, Deborah Blacker, Daniel Bos, Carol Brayne, Jean-François Dartigues, Sirwan K.L. Darweesh, Kendra L. Davis-Plourde, Frank de Wolf, Stephanie Debette, Carole Dufouil, Myriam Fornage, Jaap Goudsmit, Leslie Grasset, Vilmundur Gudnason, Christoforos Hadjichrysanthou, Catherine Helmer, M. Arfan Ikram, M. Kamran Ikram, Erik Joas, Silke Kern, Lewis H. Kuller, Lenore Launer, Oscar L. Lopez, Fiona E. Matthews, Kevin McRae-McKee, Osorio Meirelles, Thomas H. Mosley, Matthew P. Pase, Bruce M. Psaty, Claudia L. Satizabal, Sudha Seshadri, Ingmar Skoog, Blossom C.M. Stephan, Hanna Wetterberg, Mei Mei Wong, Anna Zettergren, Albert Hofman
Institutions: Harvard University, Erasmus MC, Massachusetts General Hospital, Boston University, Framingham Heart Study, University of Cambridge, Icelandic Heart Association, University of Gothenburg, University of Mississippi Medical Center, Florey Institute of Neuroscience and Mental Health, Kaiser Permanente Washington Health Research Institute, University of Washington, The University of Texas at San Antonio Health Science Center
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funders: Alzheimer's Association, GlaxoSmithKline, Sanofi, Yale University, Västra Götalandsregionen, Stiftelsen för Gamla Tjänarinnor, National Institute for Health and Care Research, European Commission, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, ZonMw, Erasmus Universiteit Rotterdam, Forskningsrådet för Arbetsliv och Socialvetenskap, VSNU Vereniging van Universiteiten, Fondation pour la Recherche Médicale, Ministerie van Onderwijs, Cultuur en Wetenschap, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Hjärnfonden, Vetenskapsrådet, Fondation de France, Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse, Université de Bordeaux, Forskningsrådet om Hälsa, Arbetsliv och Välfärd, Mutuelle Générale de l'Education Nationale, Hjartavernd, Ipsen, Janssen Prevention Center, National Institutes of Health, Novartis Pharma, Medical Research Council, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Eye Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke, Janssen Pharmaceuticals, H2020 European Research Council, FP7 Information and Communication Technologies
Awards: G1017859460, G1145951655, G1166317235, G1168103418, G1186540381, G1194337659, G1212982470, G1234092782, G1353455142, G1379949353, G1490530680, G1579733244, THE AGES STUDY - THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENUM, G1598987431, G1702986283, G1703145032, G1776849529, Dementia among 85-year-olds examined in 1986-87 and 2009, G1868975132, G1916951529, G1952670415, G2105762954, G2193588257, G2203972493, G2205403417, Origins of Alzheimer's disease across the life-course, G2257986157, G230712557, G232440474, VPH Dementia Research Enabled by IT, G250621538, G2522920215, G2630878680, G2633071985, G2637832891, G278200998, G2822918226, G2896351429, G3205625555, Microglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE Consortium, G3405256882, G343469054, CHS research resources for the cardiovascular health of older adults, G3552716425, G3580674881, G3617411373, G36433118, G3667269547, G3700699063, ADSP Follow-up in Multi-Ethnic Cohorts via Endophenotypes, Omics & Model Systems, G4045653179, G4137176464, G4261046840, G434337789, G4358921014, G4544071696, G4727311221, G4813868611, G4986752099, Mental and cognitive health in relation to functional ability and somatic health in the elderly. The influence of age, sex, birth cohort, genetic, psychological, social and neurobiological factors., G5247502409, G525443564, G5370164845, G5558075022, G5600171757, MRI, Cognitive, Genetic and Biomarker Precursors of AD & Dementia in Young Adults, G5771282042, G5936502316, G6076595154, G6237540647, G6281193135, G6370100934, G6396442921, The Framingham Heart Study, G6520098237, G6708752960, G6871811238, G6874380725, G7044523669, G715583117, G7257611415, G7264467602, G7331169431, G7336380962, G7373387228, G738203952, G7431531211, G748345579, G760388184, COGINUT : Cognition, anti-oxydants, acides gras: approche interdisciplinaire du rôle de la nutrition dans le vieillissement du cerveau, G793394869, G7959979690, G8121876622, Common mechanisms and pathways in Stroke and Alzheimer's disease., G8194827440, G8217533182, G8247000028, G849075540, Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC), G8880098891, G888387902, G8956324075, Natural history of COGnItive decline and need of CARE in the elderly -the COGINUT/3C Bordeaux-Montpellier cohort, Massachusetts Alzheimer's Disease Research Center (MADRC), G993317948
OpenAlex ID: W3082444018