Work

Temporary opening of the blood-brain barrier with the nitrone compound OKN-007.

Year: 2021

Type: article

Abstract: . This study demonstrates that OKN-007 may be able to temporarily open up the BBB to augment the delivery of various compounds ranging in MW from as small as ~550 to as large as ~470 kDa. This compound is an investigational new drug for glioblastoma (GBM) therapy in clinical trials. The translational capability for human use to augment the delivery of non-BBB-permeable drugs is extremely high.

Source: Europe PMC (PubMed Central)

Authors: Rheal A Towner, Debra Saunders, Megan Lerner, Robert Silasi Mansat, Tian Yuan, Dylan Barber, Janet Faakye, Adam Nyul-Toth, Anna Csiszar, Beverley Greenwood-Van Meerveld, Nataliya Smith

Institutions: Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, HUN-REN Szegedi Biológiai Kutatóközpont, Institute of Biophysics, Hungarian Research Network

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W3212918800

FWCI: 0.828

Cites: 19

Cited by: 9

Related to: 10