Work

Pharmacologic Inhibition of DYRK1A Results in Hyperactivation and Hyperphosphorylation of MYC and ERK Rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

Year: 2021

Type: conference-abstract

Source: Blood

DOI: 10.1182/blood-2021-144476

Authors: Christian Hurtz, Gerald Wertheim, John Chukinas, Joseph Patrick Loftus, Sung June Lee, Anil Kumar, Rahul S. Bhansali, Srividya Swaminathan, Thierry Besson, Junwei Shi, John D. Crispino, Sarah K Tasian, Martin P. Carroll

Institutions: University of Pennsylvania, Children's Hospital of Philadelphia, City Of Hope National Medical Center, City of Hope, Beckman Research Institute, Abramson Cancer Center, Centre National de la Recherche Scientifique, Laboratoire COBRA, Institut National des Sciences Appliquées Rouen Normandie, St. Jude Children's Research Hospital

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W3213027820

Cites:

Cited by:

Related to: 10