Development of Earth-Abundant Metals-Catalyzed Enantioselective Alkenylations Using Alkenyl Metal Reagents
Year: 2021
Type: article
Abstract: Allylic chiral centers are widely present in natural products and pharmaceutically active molecules, and play a vital role in the construction of organic compounds through pericyclic reactions, oxidations or reductions and other transformations.The transition metal-catalyzed asymmetric addition or coupling reaction using alkenyl metal nucleophiles is one of the most attractive strategies for the synthesis of these structures.Among the many metal catalysts, earth-abundant transition metals such as iron, cobalt, nickel and copper have been used to replace precious metals such as rhodium and palladium, and have gained attention for use in enantioselective alkenylations.Indeed, remarkable advances have been achieved with these catalysts due to their unique catalytic activity, low toxicity and environmentally friendliness.The earth-abundant transition metals are known to undergo facile one electron oxidation state changes.In the reaction process, the earth-abundant transition metals have the ability to undergo two-electron transfer and single-electron transfer processes, therefore they have more valence changes and catalytic pathways which can be exploited.Based on this, this article will review the latest research in earth-abundant metal-catalyzed enantioselective alkenylation using alkenyl metal reagents.It is divided into four sections consisting of cobalt-catalyzed enantioselective alkenylations using alkenyl metal reagents, nickel-catalyzed enantioselective alkenylations using alkenyl metal reagents, copper-catalyzed enantioselective alkenylations using alkenyl metal reagents, and other earth-abundant transition metals catalyzed enantioselective alkenylations using alkenyl metal reagents.
Source: 化学学报
DOI: 10.6023/a21070338
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W3213082744