Work

XNA enzymes by evolution and design

Year: 2021

Type: article

Abstract: The last decade has witnessed tremendous growth in the field of synthetic genetics, an area of synthetic biology that applies concepts that are commonly associated with the field of genetics, such as heredity and evolution, to artificial genetic polymers with novel backbone structures (XNAs). In addition to the emergence of biologically stable affinity reagents (aptamers), progress in this area has led to the discovery of XNA enzymes (XNAzymes) that are capable of mediating transphosphorylation chemistry with multiple turnover activity. This review explores the evolution and rational design of XNAzymes as well as their potential as reagents in biomedical applications.

Source: Current Research in Chemical Biology

DOI: 10.1016/j.crchbi.2021.100012

Authors: Turnee N. Malik, John C. Chaput

Institution: University of California, Irvine

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $1,850

Funders: National Science Foundation, W. M. Keck Foundation, Division of Chemistry