Year: 2021
Type: preprint
Abstract: Empowered by emerging concepts from physics, chemistry, and bioengineering, learning-by-building approaches have found increasing application in the life sciences. Particularly, they are directed to tackle the overarching goal of engineering cellular life from scratch. The SynCell2020/21 conference brought together a diverse group of researchers to share progress and chart the course of this field. Participants identified key steps to design, manipulate, and create cell-like entities, especially those with hierarchical organization and function. This article highlights achievements in the field, including areas where synthetic cells are having socioeconomic and technological impact. Guided by input from early-career researchers, we identify challenges and opportunities for basic science and technological applications of synthetic cells. A key conclusion is the need to build an integrated research community through enhanced communication, resource-sharing, and educational initiatives. Development of an international and interdisciplinary community will enable transformative outcomes and attract the brightest minds to contribute to the field.
Authors: Oskar Staufer, Jacqueline A. De Lora, Eleonora Bailoni, Alisina Bazrafshan, Amelie S. Benk, Kevin Jahnke, Zachary A. Manzer, Lado Otrin, Telmo Díez Pérez, Judee Sharon, Jan Steinkühler, Katarzyna P. Adamala, Bruna Jacobson, Marileen Dogterom, Kerstin Göpfrich, Darko Stefanovic, Susan R. Atlas, Michael Grunze, Matthew R. Lakin, Andrew P. Shreve, Joachim P. Spatz, Gabriel P. López
Institutions: University of Bristol, Max Planck Institute for Medical Research, Max Planck-Bristol Centre for Minimal Biology, Max Planck School Matter to Life, University of Groningen, Zernike Institute for Advanced Materials, Emory University, Cornell University, Max Planck Institute for Dynamics of Complex Technical Systems, University of New Mexico, University of Minnesota, Northwestern University, Delft University of Technology, Heidelberg University
Language: English
Subfield: Astronomy and Astrophysics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W3213637810