Work

Selective Approaches to α‐ and β‐Arylated Vinyl Ethers

Year: 2021

Type: article

Abstract: We developed simple and efficient protocols for palladium-catalyzed regioselective α- and β-arylations of structurally diverse vinyl ethers. Both catalytic methods proceed under relatively mild reactions conditions applying to a broad substrate range including more complex compounds providing arylated glucal or isochromene. Lacking the common requirement of a large reagent excess, the transformations are highly economic and limiting the waste production. Results from computational studies (DFT) provided insight into the key factors determining the pronounced regioselectivities of the investigated reactions.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.202109801

Authors: Anna Domzalska‐Pieczykolan, Ignacio Funes‐Ardoiz, Bartłomiej Furman, Carsten Bolm

Institutions: RWTH Aachen University, Universidad de La Rioja, Institute of Organic Chemistry, Polish Academy of Sciences

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,000

Funders: Narodowa Agencja Wymiany Akademickiej, Universidad de La Rioja