Bladder cancer cells prevent cisplatin-induced oxidative stress by upregulating Nestin1 expression.
Year: 2021
Type: article
Abstract: OBJECTIVE: Redox adaptation plays a critical role in cancer cells' drug tolerance and sensitivity. The antioxidative response is induced by nuclear factor erythroid 2-related factor 2 (Nrf2), which triggers the transcriptional activation of genes related to chemosensitivity, glutathione synthesis, and cell protection. Although Nestin1 is known to regulate cellular redox homeostasis by regulating Nrf2 in lung cancer cells, its regulatory effect on the antioxidative state of bladder cancer (BC) cells remains unclear. METHODS: . RESULTS: , but its knockdown improved the chemosensitivity of the cells and increased their apoptosis. CONCLUSION: These results provide a theoretical basis for further targeting the transcription factors, including Nestin1 and Nrf2, in the treatment of BC with cisplatin.
Source: PubMed
Authors: Yifan Zhang, Yunlong Li
Institution: First Affiliated Hospital of Zhengzhou University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3213677963