Year: 2021
Type: review
Abstract: There is a dire need to develop an algorithm to improve the recognition of acquired hemophilia A and B (AHA and AHB) in clinical practice. Initial and intensive care unit (ICU) management of the disorder is particular and represents a challenge for the internist/hematologist and the ICU physician. A delay in the proper treatment of bleeding episodes can lead to a life-threatening event. Expert advice should be sought as soon as possible. Succesful resolution involves accurate diagnosis, bleeding control with hemostatic and immunotherapy, and eradication of the autoantibodies to improve overall survival. Current treatment guidelines are based on the literature in the form of cases and observational studies due to a lack of randomized controlled trials. AH can be triggered by many pathologies, presenting as a paraneoplastic syndrome in case of malignancies or as surgical associated acquired hemophilia (SAHA). We have reviewed the literature from 2015 to 2021 regarding the new case reports to further assess if there is an improvement in the clinical approach.
Source: Blood Reviews
Institutions: Iuliu Hațieganu University of Medicine and Pharmacy, Spitalul Clinic Județean de Urgență Cluj-Napoca, Institute of Oncology Prof. Dr. Ion Chiricuta, Carol Davila University of Medicine and Pharmacy, Institutul Clinic Fundeni, Jagiellonian University, Szpital Uniwersytecki w Krakowie, Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, National Health Laboratory Service, University of the Witwatersrand, Johannesburg Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,200
OpenAlex ID: W3213726393