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Description of Major Osteoporotic Fractures in Women with Invasive Breast Cancer Who Received Endocrine Therapy

Year: 2021

Type: article

Abstract: a International Classification of Diseases, 9th Revision (ICD-9) codes were used to ascertain fracture diagnoses for clinical adjudication.Fracture adjudication was conducted by a physician with expertise in skeletal health supported by a medical records analyst.Incident fractures were identified by acute or subacute characteristics, evidence of ongoing fracture healing, or in the case of vertebral fracture, acute and subacute findings or clinical notes indicating an acute event, presentation, or clearly localizing symptoms.Pathologic (cancer-related) fractures were differentiated from nonpathologic fractures by imaging features, histopathology, evidence of osseous metastases, oncology physician assessment, or targeted treatment (eg, localized radiation therapy).Prevalent vertebral fractures were determined based on previous vertebral fracture history or incidental identification of vertebral fracture of indeterminant age in a patient without an acute event or clearly localizing symptoms.These included a few fractures occurring sometime after breast cancer diagnosis but were prevalent fractures when they were incidentally discovered.Fractures associated with hospitalized major trauma (ICD-9 E800-E848) were excluded.

Source: JAMA Network Open

DOI: 10.1001/jamanetworkopen.2021.33861