Data from: Indirect protection from vaccinating children against influenza in households
Year: 2018
Type: article
Abstract: Vaccination is an important intervention to prevent influenza virus infection, but indirect protection of household members of vaccinees is not fully known. Here, we analyze a cluster household randomized control trial, with one child in each household randomized to receive vaccine or placebo, for an influenza B epidemic in Hong Kong. We apply statistical models to estimate household transmission dynamics and quantify the direct and indirect protection of vaccination. Direct vaccine efficacy is 71%. The infection probability of unvaccinated household members in vaccinated households was only 5% lower than in control households, because only 10% of infections are attributed to household transmission. Even when that proportion rises to 30% and all children are vaccinated, we predict that the infection probability for unvaccinated household members is only reduced by 20%. This suggests that benefits of individual vaccination remain important even when other household members are vaccinated.
Institutions: University of Hong Kong, Institut Pasteur
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3214426550