Work

The association of motoric cognitive risk with incident dementia and neuroimaging characteristics: The Atherosclerosis Risk in Communities Study

Year: 2021

Type: article

Study design: Observational Study

Abstract: INTRODUCTION: Motoric cognitive risk (MCR), a clinical syndrome characterized by slow gait speed and subjective cognitive complaints, has been associated with dementia risk. The neuropathological features underlying MCR remain poorly understood. METHODS: The Atherosclerosis Risk in Communities (ARIC) community-based cohort study classified participants using standardized criteria as MCR+/- and mild cognitive impairment (MCI)+/- at study baseline (2011-2013). We examined the 5-year dementia risk and baseline brain structural/molecular abnormalities associated with MCR+ and MCI+ status. RESULTS: Of 5023 nondemented participants included, 204 were MCR+ and 1030 were MCI+. Both MCR+ and MCI+ participants demonstrated increased dementia risk. The pattern of structural brain abnormalities associated with MCR+ differed from that of MCI+. Whereas MCI+ was associated with comparatively smaller volumes in brain regions vulnerable to Alzheimer's disease pathology, MCR+ status was associated with smaller volumes in frontoparietal regions and greater white matter abnormalities. DISCUSSION: MCR may represent a predementia syndrome characterized by prominent white matter abnormalities and frontoparietal atrophy.

Source: Alzheimer s & Dementia

DOI: 10.1002/alz.12412

Authors: Gabriela T. Gomez, Rebecca F. Gottesman, Kelley Pettee Gabriel, Priya Palta, Alden L. Gross, Anja Soldan, Marilyn S. Albert, Kevin J. Sullivan, Clifford R. Jack, David S. Knopman, B. Gwen Windham, Keenan A. Walker

Institutions: Johns Hopkins University, Johns Hopkins Medicine, University of Alabama at Birmingham, Columbia University Irving Medical Center, Columbia University, University of Mississippi Medical Center, Mayo Clinic, National Institute on Aging

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Mayo Clinic, Eli Lilly and Company, Biogen, University of Southern California, Eisai, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke, National Center for Research Resources

Awards: G1114307781, G1201667161, G1255514405, G1262629770, G1304508731, G1328425623, G140664742, G1522370804, G1589692941, G2117773213, G2195207551, G2262505034, The ARIC-PET Amyloid Imaging Study, G2468260354, G2568281471, G2607172802, G2655192887, G2701926366, G293741327, G3103017843, G3265445872, G3329506677, G3744596180, G3941192350, G3973572274, G4068323944, G4230684217, G4290615481, G445457422, G4597579782, ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5, G4739409156, G4747441672, G4790942633, G4845182219, G5023962947, G536099884, G5364873420, G5464419710, G5556898879, G5622883882, G5770678025, G583528397, G5928944960, G5981726443, G5999060983, G6209487210, G6322445267, G6483657930, G6594067713, ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5, ARIC Neurocognitive Study (ARIC-NCS), G6837735701, G6863459535, G6978868085, G706815212, G7132376052, G7155745631, G7535686976, G7799800877, G7806539067, G7808459314, G8738262636, Systemic- and neuroinflammation and the progression of Alzhemer's disease, G8937114048, G8951135482, G8976278160, G899128061, G9000015399, G9000023984, G9000038488, G9000053661, G9000071824, G9000074502, G9000155543, G9000165945, G9000267281, G901665369, G968738093

OpenAlex ID: W3214618379

FWCI: 3.315

Cites: 48

Cited by: 33

Related to: 10