S7 Estimating the potential impact of residual EDS on the QoL of patients with OSA and, for the first time, their partners, using a time trade-off methodology
Year: 2021
Type: conference-paper
Study design: Observational Study
Abstract: Introduction and Objectives Excessive daytime sleepiness (EDS) is a common symptom of obstructive sleep apnoea (OSA), persisting in 9% to 22% of patients despite primary airway therapy (residual EDS). EDS can impair work productivity and driving ability, and negatively impact quality of life (QoL) of patients and their partners. This study aimed to elicit QoL values (utilities) from a societal perspective for patients with OSA with residual EDS of varying severity and, for the first time, for the partners of these patients, using a novel time trade-off (TTO) approach. Methods Utility values for health states of varying severities of residual EDS in OSA were elicited using the TTO method in a study conducted with a United Kingdom general public sample (N=110). Four EDS severity health state descriptions were developed from both patient and partner perspectives (no EDS, mild EDS, moderate EDS, severe EDS). During face-to-face interviews, participants were asked to ‘trade off’ time for each EDS health state for a shorter period in full health (0–10 years), first for the patient health states and then for the partner health states. TTO responses were converted to utility values (scale of 0–1, where 0 represents QoL equivalent to death and 1 represents the highest QoL). Results Mean utility scores declined with increasing EDS severity (table 1). In the context of the TTO exercise, participants were prepared to trade a mean of 4.5 life-years (out of a maximum of 10) to avoid the QoL consequences of severe EDS compared with best imaginable health and 3.3 life-years to avoid the QoL impact associated with being the partner of a patient with severe EDS. Conclusions These results demonstrate the high potential impact of residual EDS on the QoL of patients with OSA and their partners. Estimated utility values for patients and partners declined with increased EDS severity. This is the first time that the impact of residual EDS in OSA on QoL and utility has been measured from the partner perspective, highlighting the range of potential benefits that could result from the use of novel treatment options (alongside primary airway therapy) for residual EDS. Please refer to page A188 for declarations of interest related to this abstract.
Authors: K Tolley, S Mettam, J Noble-Longster, R Hibbs, L Stainer, M Cawson, T Snell, A Manuel
Institution: Liverpool University Hospitals NHS Foundation Trust
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W3214645810