Work

A Chiral, Dendralenic C–H Acid

Year: 2021

Type: article

Abstract: We report the synthesis of a chiral dendralenic C–H acid, which contains three unsubstituted binaphthyl moieties. This motif and an achiral variant can be made from their corresponding bis(sulfone) precursors in one step. Despite the presence of the enantiopure binaphthyl backbone, the newly designed chiral C–H acid showed only poor enantioselectivity in a Mukaiyama aldol reaction. First attempts toward the synthesis of 3,3′-hexasubstituted binaphthyl-based dendralenic acids are also reported.

Source: Synlett

DOI: 10.1055/a-1705-9786

Authors: Benjamin List, Denis Höfler

Institutions: Max-Planck-Institut für Kohlenforschung, Thieme Medical Publishers (Germany)

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: Deutsche Forschungsgemeinschaft, Horizon 2020 Framework Programme, Leibniz-Gemeinschaft

Award: G503016360