Year: 2013
Type: article
Abstract: The proteins Mdm2 and MdmX are critical negative regulators of the tumor suppressor p53 and, when overexpressed, they function as oncogenes. However, recent research has shown MdmX to function as a tumor suppressor in p53-deficient mice and to increase genome stability in p53-deficient mouse cells. This project investigates the effect of MdmX on genomic stability in human breast cancer cells. The results show a correlation between MdmX and a decrease in multipolar spindles, along with an increase in chromosome number. These findings could provide a fundamental understanding of the role of genomic stability in human cancer.
Source: Digital WPI
Author: Kevin Woods
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W3215103903