Work

Multiomic characterization of oncogenic signaling mediated by wild-type and mutant RIT1

Year: 2021

Type: article

Abstract: Both normal and mutant forms of the GTPase RIT1 elicit oncogenic changes similar to mutant RAS in lung epithelial cells.

Source: Science Signaling

DOI: 10.1126/scisignal.abc4520

Authors: April Lo, Kristin Holmes, Shriya Kamlapurkar, Filip Mundt, Sitapriya Moorthi, Iris Fung, Shaunt Fereshetian, Jacqueline Watson, Steven A. Carr, Philipp Mertins, Alice H. Berger

Institutions: University of Washington, Fred Hutch Cancer Center, Broad Institute, Harvard University, Karolinska Institutet, Massachusetts Institute of Technology

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: G1192909070, G2772484042, G352412733, G412812484, Center of Excellence for High Throughput Proteogenomic Characterization, Training in Cellular and Molecular Biology, MICROSCALED PROTEOGENOMICS FOR CANCER CLINICAL TRIALS, Cancer Center Support Grant

OpenAlex ID: W3215378693

FWCI: 1.14

Cites: 50

Cited by: 22

Related to: 10