Editorial: Cognitive Impairment and Inflammation in Old Age and the Role of Modifiable Risk Factors of Neurocognitive Disorders
Year: 2021
Type: editorial
Abstract: So far, numerous functional and structural modifications related to normal brain aging have been reported and indicated that brain mass decreases in the order of 2%-3% per decade after the age of 50, and in subjects 80 years or older, brain mass reduces 10% in comparison young adults (Drachman, 2006). However, cognitive decline during aging diverges considerably, with some older people demonstrating normal cognitive skills (Deary et al., 2009). Cognitive aging is a complex, multifactorial concept involving biological mechanisms such as immunosenescence, vascular aging, and brain aging. It is characterized by a decline in memory, other cognitive processes, changes in behaviors, and impaired ability to live an independent and high functioning life (Cunningham & Hennessy, 2015). Additionally, it is a broad concept that comprises more than 100 diseases leading to dementia that has in common a progressive reduction in cognitive performance in old age. However, cognitive impairment could also appear across other psychiatric disorders aggravating their course and enormously compromising those patients with aging (Fourrier et al., 2019).Recently, some researchers suggested a relationship between inflammatory processes and cognition. They have emphasized a close association between some aspects of the immune system, increasing the permeability of the bloodbrain barrier and processes at the level of the neuron and vascular systems,
Source: Frontiers in Psychiatry
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,950
OpenAlex ID: W3215596225