Work

Polymer End Group Control through a Decarboxylative Cobalt-Mediated Radical Polymerization: New Avenues for Synthesizing Peptide, Protein, and Nanomaterial Conjugates

Year: 2021

Type: article

Abstract: Cobalt-mediated radical polymerizations (CMRPs) have been initiated by the radical decarboxylation of tetrachlorophthalimide activated esters. This allows for the controlled radical polymerization of activated monomers across a broad temperature range with a single cobalt species, with the incorporation of polymer end groups derived from simple carboxylic acid derivatives and termination with an organozinc reagent. This method has been applied to the synthesis of a polymer/graphene conjugate and a water-soluble protein/polymer conjugate, demonstrating the first examples of CMRP in graphene and protein conjugation.

Source: JACS Au

DOI: 10.1021/jacsau.1c00453

Authors: Meri Ayurini, Peter G. Chandler, Paul D. O’Leary, Ruoxin Wang, David Rudd, Karen D. Milewska, Lara R. Malins, Ashley M. Buckle, Joel F. Hooper

Institutions: Universitas Pertamina, Monash University, Australian National University

Language: English

Topic: Advanced Polymer Synthesis and Characterization

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $5,000

OpenAlex ID: W3215603660

FWCI: 0.595

Cites: 54

Cited by: 10

Related to: 10