Work

Anaphylaxis and Mast Cell Disorders

Year: 2021

Type: review

Abstract: There is strong evidence of an association between severe anaphylaxis, especially hymenoptera venom induced, and mast cell (MC) disorders. It has been thought that intrinsic abnormalities in MCs, including the presence of the activating KIT D816V mutation in mastocytosis or of genetic trait, hereditary alpha-tryptasemia, may influence susceptibility to severe anaphylaxis. This article evaluates the potential mechanisms leading to severe MC activation, as well as the differential diagnosis of and range of symptoms attributable to MC mediator release. Also, we offer a global classification for disorders related to MC activation.

Source: Immunology and Allergy Clinics of North America

DOI: 10.1016/j.iac.2021.09.007

Authors: Theo Gülen, Cem Akin

Institutions: Karolinska University Hospital, Karolinska Institutet, University of Michigan, Michigan Medicine

Language: English

Topic: Mast cells and histamine

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,360