Year: 2021
Type: article
Abstract: Photoacoustic (PA) imaging is a nonradioactive and noninvasive imaging modality that can volumetrically map the distribution of photo-absorbing molecules with deeper tissue penetration than optical modalities. Here, we report on a convenient strategy to synthesize a modular methylene blue tetrazine (MB-Tz) PA imaging agent and a trans-cyclooctene (TCO)-labeled bisphosphonate (TCO-BP) calcium metabolism targeting vector. PA imaging of MB-Tz pre-clicked to TCO-BP demonstrated significant signal in regions of active bone metabolism (knee and shoulder joints) at 1 h post-injection. Targeting validation and whole-body biodistribution studies were carried out with the radiolabeled pre-clicked product of MB-Tz with 99mTc-TCO-BP, confirming uptake in knees and shoulders at 1 h post-injection.
Institution: McMaster University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,500
Awards: G198999915, G3237245144, G3386713176
OpenAlex ID: W3216360413