From Hair to Heart: Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Simultaneously Differentiate Into Mature Cardiomyocytes and Atrial Myocytes
Year: 2021
Type: preprint
Abstract: Hair-follicle-associated pluripotent (HAP) stem cells express nestin, and are located in the bulge area of hair follicles and can differentiate to numerous types of cells. In the present study, we demonstrate that rat HAP stem cells simultaneously differentiated to mature cardiomyocytes and atrial myocytes. The addition of isoproterenol, activin A, bone morphogenetic protein 4 (BMP 4), basic fibroblast growth factor (bFGF), and cyclosporin A (CSA), induced simultaneously differentiation of HAP stem cells to c-kit-positive cardiomyocytes and MLC-2a-expressing atrial myocytes. The results of the present study suggest that HAP stem cells differentiating to cardiomyocytes and atrial myocytes have future clinical potential for heart regeneration.
Source: Research Square
Institutions: Kitasato University, AntiCancer (United States)
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Establishment of myocardial induction method from autologous hair follicle stem cell-derived stem cells under hypoxic environment and regenerative medicine for heart failure, Regenerative medicine of spinal cord injury and heart failure using biomaterial including hair-follicle-associated pluripotent (HAP) stem cells
OpenAlex ID: W3216614609