Work

Drug-device pairing in noninvasive brain stimulation

Year: 2021

Type: article

Abstract: Noninvasive brain stimulation (NBS) protocols are emerging as realistic treatment options in a range of neurologic and psychiatric disease. Yet NBS efficacy in clinical trials remains incomplete in essentially all disorders where these have been deployed. Among the mechanisms by which improved understanding of how common NBS protocols modulate cortical excitability may lead to improved clinical efficacy are prospects for logical drug-device pairings. In this presentation, Dr. Rotenberg will focus on transcranial direct current stimulation (tDCS) as a representative NBS protocol, and describe a proposed pipeline for modeling tDCS in vivo in a mouse, mapping the molecular and cellular pathways engaged by tDCS in vitro in isolated mouse slices, testing whether such biology is relevant to humans by in vitro studies of tDCS in isolate human brain slices (derived from epilepsy surgery), and then formulating human, clinical drug-device protocols. Keywords: tDCS, NMDA, cortex

Source: Brain stimulation

DOI: 10.1016/j.brs.2021.10.538

Author: Alexander Rotenberg

Institution: Boston Children's Hospital

Language: English

Topic: Transcranial Magnetic Stimulation Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,310