Work

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation.

Year: 2015

Type: article

Abstract: The success or failure of allogeneic stem cell transplantation (SCT) in curing a variety of hematological disorders, centers to a large extent on the quality of the immune recovery of the donor graft. As well as exerting a graft-versus-malignancy effect, critical in achieving cure of hematological malignancies, donor T lymphocytes confer protective immunity against resident viruses that reactivate during the period of profound immunosuppression following the graft. As they engraft alloreacting donor T lymphocytes can cause life-threatening graft versus host disease (GVHD).

Source: PubMed Central

DOI: 10.3978/j.issn.2305-5839.2015.01.18

Authors: Austin John Barrett, Catherine M Bollard

Institutions: National Institutes of Health, Children's National, George Washington University, National Heart, Lung, and Blood Institute

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute