Perspectives immunoprophylactiques et immunothérapeutiques contre les maladies à prions
Year: 2006
Type: article
Abstract: Prion diseases or transmissible subacute spongiform encephalopathies (TSSE) are fatal neurodegenerative conditions, for which there is so far no known treatment or prevention. Promising results achieved in the field of Alzheimer disease give however some reasons to hope that individuals with the disease or individuals at risk might benefit from similar immunoprophylactic or immunotherapeutic approaches. This article reviews current knowledge on the immunology of prion diseases. In the first section we describe the known routes of prion lymphoinvasion from the periphery to the sites of neuroinvasion. The second section focuses on the mediators of innate immunity mobilized within the central nervous system and on their ambivalent role in the pathogenesis of the disease. The final section describes the vaccine approaches aimed at stimulating adaptive immunity and at creating, in association with the mediators of the innate immune system, a defence barrier against prions.
DOI: 10.4267/2042/47808
Authors: Claude Carnaud, Véronique Bachy
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2066653825