Work

Inhibition of cytochrome systems of heart muscle and certain bacteria by the antagonists of dihydrostreptomycin: 2-alkyl-4-hydroxyquinoline N-oxides

Year: 1956

Type: article

Abstract: Antagonism of streptomycin activity by culture filtrates of Pseudononas aerugino8a was first reported by Sureau, Arquie, Boyer & Saviard (1948).The factor responsible for the antagonism was isolated (Lightbown, 1954) and was shown by Cornforth & James (1954, 1956) to be a mixture of 2-alkyl-4-hydroxyquinoline N-oxides.The present paper describes an investigation of some of the biological properties of these compounds; part of this work has already been briefly reported (Lightbown & Jackson, 1954; Jackson & Light- bown, 1955). METHODS AND MATERIALS Assay of dihydrostreptomycin antagonist activity.A modified cup-plate diffusion method (Lightbown, 1954) was employed.Cups containing the solutions of the quino-

Source: Biochemical Journal

DOI: 10.1042/bj0630130

Authors: J. W. Lightbown, F. L. Jackson

Institutions: King's College London, King's College Hospital, National Institute for Medical Research

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W345669585