Temporal Changes in Skin Erythema Induced by Fractionated Radiotherapy Simulated by Using the Time-dependent Linear-quadratic Model (Original)
Year: 2015
Type: article
Abstract: Radiotherapy with ionizing radiation for the treatment of cancer is fractionated to increase its efficacy and to decrease its adverse effects.Radiotherapy for breast cancer targets all the mammary gland tissue immediately below the skin, and therefore, broad exposure of the skin to radiation is unavoidable.Radiation -induced skin erythema results in intolerable anxiety.In order to relieve axiety, it is important to explain to patients the dermatological changes that may occur during and after radiotherapy.We used a spectrophotometer to measure the severity of the erythema caused by radiotherapy after breast conserving surgery for breast cancer.In this study, radiation -induced erythema was quantified and the values were incorporated into a newly developed generalized linear quadratic model to reproduce the temporal changes on a virtual radiation field.This simulation model will be useful not only for patients' but also for medical students' education.(
Authors: Sekine Hiroshi, Kenji Suzuki
Institution: Jikei University School of Medicine
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W360127321