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Therapeutic Approaches to Aggressive Carcinomas Based on a Novel VEGF/Neuropilin Autocrine Pathway

Year: 2020

Type: article

Abstract: Summary: Autocrine VEGF signaling in tumor cells contributes to de-differentiation and function of tumor initiating/stem cells. NRP2 is the nexus of a signaling pathway that promotes de-differentiation and sustains tumor initiating/stem sells. Anti-NRP2 therapy is worth pursuing, especially for high-grade cancers. Therapeutic Abs are available. This presentation was part of the retreat mini-symposium entitled: Biomarker Discovery and Targeted Therapeutics in Cancer.

Source: The Journal of the American Medical Association (JAMA) Network (American Medical Association)

DOI: 10.13028/ehpx-3v71

Authors: Goel, Hira Lal, Mercurio, Arthur M.

Language: English

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W375352650

FWCI:

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