The Association among Serum Leptin, Insulin and Insulin Resistance in Iraqi Patients with Cholelithiasis
Year: 2015
Type: article
Study design: Observational Study
Abstract: Gallstone disease (GD): is a common condition all over the world as well as in Iraq .It is a chronic recurrent hepatobiliary disease, the basis for which is the impaired metabolism of cholesterol, bilirubin and bile acids. The aim of this study is to investigate the association between serum leptin and insulin, insulin resistance and cholelithiasisand serum electrolyte and cholelithiasis.Fifty patients with GD, aged between 16 to 83 years attending in AL-Yarmouk teaching hospital in Baghdad, Iraq (between December 2013 and May 2014) were included in the present study, also forty normal persons, aged (19-77 years) who serve as control group. The result shows a significant increasing in the mean of fasting serum glucose, Homeostatic Model Assessment [HOMA], VLDL, AST, ALP and iron, and a significant decreasing in the means of HDL, sodium, chloride of patients compared to controls. From the present study, the following can be concluded: hyperinsulinemia, hyperglycaemia, insulin resistance, increase leptin level, abnormal changes of lipoprotein, abnormal changes in liver functions, mineral and increase in BMI. All of these parameters are associated with cholelithiasis.
Authors: Bushra F. Hasan, Samer A. Muhi, Noor Ibrahim
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W385666863