Year: 2014
Type: report
Abstract: This study is a comparison and exploration of next generation sequencing algorithms and tools.A simulation study was done to compare the performance of edgeR, DESeq, and baySeq in detecting differential gene expression.The methods were compared in context of a balanced pairwise design.The simulation results suggest that the methods are comparable under the conditions simulated.The study also explored real data comprised of one biological replicate between two treatments.Cufflinks and CummerRBund were used to detect differential gene expression.The visualization results from the real data suggest no differential expression is present.I would like to express my special appreciation and thanks to my advisor Dr. Doina Caragea, you have been a tremendous mentor.Your advice on both my report and career has been very valuable.I would like to thank my committee members
Author: Heath Yates
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: National Science Foundation
OpenAlex ID: W39531172