Responses in the Basal Forebrain Cholinergic System to Aging
Year: 2002
Type: book-chapter
Abstract: Documentation of age-related mental deficiency, described as the decline and decay of the human body and regression of mental capacities by 63- and 81-yr-of-age, dates to the description of the life cycle by Pythagoras, a Greek physician of the 7th century B.C. He described the late stage of life where “the scene of mortal existence closes, after a great length of time,... The system returns to the imbecility of the first epoch of the infancy.” The more modern description of senile dementia dates to Alois Alzheimer’s description in 1906 of the first documented case of Alzheimer’s disease (AD) (1). During the last quarter of this century there has been significant progress in the fields of neuropathology, biochemistry, and genetics, as well as some pharmatherapeutic interventions aimed at this dementing disorder. However, there is no definitive characterization of the mechanisms of this disease (2).
Source: Humana Press eBooks
Authors: Zezong Gu, J. Regino Perez-Polo
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W39687218