Loss of neuronal ERα abolishes sexual and aggressive behaviors in male mice
Year: 2013
Type: article
Abstract: The estrogen receptor a knockout mice (aERKO) underscores the importance of ERa. expression in the regulation of social behaviors by estrogen. We investigate the neuronal contribution to both social and nonsocial behaviors by using male mice in which the ERa gene is deleted solely in neurons. Overall, these mice showed similar behavioral changes as those previously reported in aERKO mice. Both sex and aggressive behaviors were completely abolished in these mice. ERa deficient mice also tended to show higher levels of locomotor activity measured in open field test and tended to be heavier than wild-type control mice. These findings suggest that neuronal ERa may playa major role in the regulation of male social behaviors.
Authors: Kazuhiro Sano, Kazuyo Nagata, Mariko Makata
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W399921064