Year: 2014
Type: article
Abstract: CNS -1: Is there a significant probability that space radiation would lead to immediate or acute functional changes in the CNS during a long-term space mission and if so what are the mechanisms of change?Are there threshold doses for these effects?CNS -2: Is there a significant probability that space radiation exposures would lead to long-term or late degenerative CNS risks if so what are the mechanisms of change?CNS -3: How does individual susceptibility including hereditary pre-disposition (Alzheimer's, Parkinson's, apoE) and prior CNS injury (concussion or other) alter significant CNS risks?Does individual susceptibility modify possible threshold doses for these risks in a significant way?CNS -4: What are the most effective biomedical or dietary countermeasures to mitigate CNS risks?By what mechanisms are the countermeasures likely to work?CNS -5: How can new knowledge and data from molecular, cellular, tissue and animal models of acute CNS risks or clinical human data, including altered motor and cognitive function and behavioral changes be used to estimate acute CNS risks to astronauts from GCR and SPE? CNS -6: How can new knowledge and data from molecular, cellular, tissue and animal models of late CNS risks or clinical human date be used to estimate late CNS risks to astronauts from GCR and SPE?CNS -7: What are the best shielding approaches to protect against CNS risks, and are shielding approaches for CNS and cancer risks synergistic?CNS -8: Are there significant CNS risks from combined space radiation and other physiological or space flight factors (e.g., sleep deprivation, psychological, microgravity, immune-endocrine systems or other)? CNS Gaps
Author: Janice L. Huff
Institution: Johnson Space Center
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W41576676