Year: 2023
Type: article
Abstract: The prefrontal cortex (PFC) has dramatically expanded in primates, but its organization and interactions with other brain regions are only partially understood. We performed high-resolution connectomic mapping of the marmoset PFC and found two contrasting corticocortical and corticostriatal projection patterns: "patchy" projections that formed many columns of submillimeter scale in nearby and distant regions and "diffuse" projections that spread widely across the cortex and striatum. Parcellation-free analyses revealed representations of PFC gradients in these projections' local and global distribution patterns. We also demonstrated column-scale precision of reciprocal corticocortical connectivity, suggesting that PFC contains a mosaic of discrete columns. Diffuse projections showed considerable diversity in the laminar patterns of axonal spread. Altogether, these fine-grained analyses reveal important principles of local and long-distance PFC circuits in marmosets and provide insights into the functional organization of the primate brain.
Source: Neuron
Institutions: RIKEN Center for Brain Science, RIKEN, National Institutes of Natural Sciences, Kyoto University, The Exploratory Research Center on Life and Living Systems, National Center of Neurology and Psychiatry, National Institute of Neuroscience, University of Indonesia, Jichi Medical University, Tokyo Metropolitan University, Washington University in St. Louis, Keio University, Central Institute for Experimental Animals
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $9,080
Funders: Japan Agency for Medical Research and Development, Ministry of Education, Culture, Sports, Science and Technology, National Institutes of Health, Japan Society for the Promotion of Science, RIKEN, National Institute of Mental Health, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering, Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences
Awards: FluoRender: Visualization-Based and Interactive Analysis for Multichannel Microscopy Data, G169325803, G2228501596, G2410033778, Reconstructions and Representations of Cerebral Cortex, G299391346, G6151296658, Center for Integrative Biomedical Computing, G6823725078, Center for Integrative Biomedical Computing Legacy Transition, G7608249155, G9000154966
OpenAlex ID: W4376891553