Detection of Chrysin as Agent for potential treatment of Alzheimer's Disease using Electrochemical sensor Based on CuO@Ta2O5 nanocomposite Modified Glassy Carbon Electrode
Year: 2021
Type: article
Abstract: In this work, the CuO@Ta 2 O 5 nanocomposite was synthesized, and the chemical stability and sensing capabilities of the CuO@Ta 2 O 5 nanocomposite as a chrysin sensor were improved. The nanocomposite was electrodeposited on a glassy carbon electrode (GCE), and structural analyses using SEM and XRD indicated that the GCE was uniformly coated with high porosity CuO@Ta 2 O 5 nanoparticles. The amperometry and cyclic voltammetry experiments showed the high sensitive, selective, stable and accurate response of CuO@Ta 2 O 5 /GCE to chrysin determination because of the formation of a hetero-interface between CuO and Ta 2 O 5 nanostructures, which facilitates charge migration and enhances the catalytic activity of CuO@Ta 2 O 5 /GCE. Results showed that the linear range, detection limit and sensitivity were obtained at 10 to 100μM, 0.008μM and 0.92921μA/μM, respectively. The practicality of the proposed electrochemical sensor in real samples was studied and results indicated the obtained recovery (96.00% to 98.00%) and RSD (2.77% to 3.11%) values were acceptable, illustrating that CuO@Ta 2 O 5 /GCE can be used as a practical sensor to detect chrysin in pharmaceutical and biological samples.
DOI: 10.20964/2021.09.10
Authors: Lin Fu, Xuexia Wang
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,670
OpenAlex ID: W4200107058