Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi
Year: 2022
Type: article
Abstract: Serological markers are a promising tool for surveillance and targeted interventions for Plasmodium vivax malaria. P. vivax is closely related to the zoonotic parasite P. knowlesi, which also infects humans. P. vivax and P. knowlesi are co-endemic across much of South East Asia, making it important to design serological markers that minimize cross-reactivity in this region. To determine the degree of IgG cross-reactivity against a panel of P. vivax serological markers, we assayed samples from human patients with P. knowlesi malaria. IgG antibody reactivity is high against P. vivax proteins with high sequence identity with their P. knowlesi ortholog. IgG reactivity peaks at 7 days post-P. knowlesi infection and is short-lived, with minimal responses 1 year post-infection. We designed a panel of eight P. vivax proteins with low levels of cross-reactivity with P. knowlesi. This panel can accurately classify recent P. vivax infections while reducing misclassification of recent P. knowlesi infections.
Source: Cell Reports Medicine
Authors: Rhea J. Longley, Matthew J. Grigg, Kael Schoffer, Thomas Obadia, Stephanie Hyslop, Kim A. Piera, Narimane Nekkab, Ramin Mazhari, Eizo Takashima, Takafumi Tsuboi, Matthias Harbers, Kevin Tetteh, Chris Drakeley, Chetan E. Chitnis, Julie Healer, Wai-Hong Tham, Jetsumon Sattabongkot, Michael T. White, Daniel J. Cooper, Giri S. Rajahram, Bridget E. Barber, Timothy William, Nicholas M. Anstey, Ivo Mueller
Institutions: The University of Melbourne, Walter and Eliza Hall Institute of Medical Research, Charles Darwin University, Menzies School of Health Research, Institut Pasteur, Université Paris Cité, Ehime University, Proteo-Science Center, Ehime University, CellFree Sciences (Japan), RIKEN Center for Integrative Medical Sciences, London School of Hygiene & Tropical Medicine, Mahidol University, University of Cambridge, Queen Elizabeth Hospital
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,200
Funders: Wellcome Trust, Australian Government, State Government of Victoria, Kementerian Kesihatan Malaysia, Walter and Eliza Hall Institute, Medical Research Council, National Health and Medical Research Council, Australian Centre for International Agricultural Research, Japan Society for the Promotion of Science, National Institute of Allergy and Infectious Diseases
Awards: Assessing the impact of Ripr genetic diversity on ex vivo malaria parasite growth inhibition assay., Molecular Mechanisms of Malaria Parasite Invasion, Senior Research Fellowship, Identification of host proteins interacting P. falciparum infected RBC surface antigens, G1963427263, Leveraging naturally acquired immune responses to malaria to advance control and elimination of this disease, Pathophysiology and treatment of malaria in our region, G3473867631, Understanding malaria in the human host, Comprehensive analyses of RBC-malaria parasite PPI interactome, Tropical diseases: Translating discoveries into better health, Risk factors, mechanisms, and treatment of knowlesi malaria, Tropical Disease - immunity, pathogenesis and vaccine development: global translation, Comparative pathophysiology of severe knowlesi and falciparum malaria, Centre for Research Excellence in Malaria Elimination, Emerging zoonotic malaria in Malaysia: strengthening surveillance and evaluating population genetic structure to improve regional risk prediction tools
OpenAlex ID: W4283271026