Work

GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi’s Sarcoma-Associated Herpesvirus-Induced Cellular Transformation

Year: 2021

Type: article

Abstract: By performing a genome-wide CRISPR-Cas9 screening, we have identified cellular epigenetic regulators that are essential for KSHV-induced cellular transformation. Among them, GRWD1 regulates epigenetic active mark H3K4me3 by interacting with WDR5 and MLL2 and recruiting them to chromatin loci of specific genes in KSHV-transformed cells. Hence, KSHV hijacks the GRWD1-WDR5-MLL2 complex to remodel cellular epigenome and induce cellular transformation. Since the dysregulation of GRWD1 is associated with poor prognosis in several types of cancer, GRWD1 might also be a critical driver in other viral or nonviral cancers.

Source: mBio

DOI: 10.1128/mbio.03431-21

Authors: Shan Wei, Songjian Lu, Lifan Liang, Xian Wang, Wan Li, Tingting Li, Luping Chen, Enguo Ju, Xinquan Zhang, Zhao Lai, Yufei Huang, Xinghua Lu, Shou-Jiang Gao

Institutions: University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, The University of Texas at San Antonio Health Science Center

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: Cancer Prevention and Research Institute of Texas, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Dental and Craniofacial Research, U.S. National Library of Medicine

Awards: G1216480350, Mays Cancer Center at UT Health SA, Targeting KSHV malignancies and persistent infection, HISTONE MODIFIERS IN ORAL KSHV INFECTION AND MALIGNANCIES, High Throughput DNA Sequencer: Illumina HiSeq 3000 Sequencer, KSHV microRNAs in tumor invasion and angiogenesis, G4262861352, UTHSCSA Cancer Genome Sequencing and Computation Core, G665014422, G6902112798, G7776704944, Mechanism of KSHV-induced angiogenesis, G8340401572, Regulation of KSHV replication by N6-methyladenosine (m6A), Interpretable deep learning models for translational medicine Renewal, Cancer Center Support Grant, Cell model for KSHV infection and genetic manipulation

OpenAlex ID: W4200166560

FWCI: 0.18

Cites: 66

Cited by: 7

Related to: 10