Neonatal Birthweight, Infant Feeding, and Childhood Metabolic Markers
Year: 2021
Type: article
Abstract: OBJECTIVE: Antenatal and early neonatal nutritional environment may influence later metabolic health. Infants of mothers with gestational diabetes mellitus (GDM) have higher risk for childhood obesity and metabolic syndrome (MetS). Leptin and adiponectin are known biomarkers for MetS and may guide interventions to reduce later obesity. We sought to examine the relationship between birthweight, early infancy feeding practices, and biomarkers for MetS in offspring of women with mild GDM. STUDY DESIGN: Secondary analysis of a prospective observational follow-up study on the offspring of women who participated in a multicenter randomized treatment trial on mild GDM. Children were evaluated by research coordinators and biospecimens collected at the age of 5 to 10. Plasma concentrations of leptin and adiponectin were compared between large for gestational age (LGA) and average birthweight (AGA) infants, and according to whether solid foods were introduced early (<6 months of age) or at the recommended age (≥6 months of age). Multivariable analysis adjusted for fetal sex, race/ethnicity, and maternal body mass index. RESULTS: = 0.85, respectively). After controlling for covariates, children who were LGA and AGA at birth had similar leptin concentrations. CONCLUSION: Birthweight and early infancy feeding practice are not associated with alterations in leptin and adiponectin in children of women with mild GDM. KEY POINTS: · Adipocytokines are markers of metabolic status.. · Children of women with mild GDM may be at risk for MetS.. · Biomarkers similar in LGA and AGA groups.. · Biomarkers similar in early and delayed solid-fed groups.. · Nonhuman milk does not modify effect of feeding practice..
Source: American Journal of Perinatology
Authors: Jessica Pippen, Bethany Stetson, Lindsay Doherty, Michael W. Varner, Brian M. Casey, Uma M. Reddy, Ronald J. Wapner, Dwight J. Rouse, Alan T. N. Tita, John M. Thorp, Edward K. Chien, George R. Saade, Sean C. Blackwell, for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units Network
Institutions: The Ohio State University, Northwestern University, George Washington University, University of Utah, University of Utah Health Care, The University of Texas Southwestern Medical Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Columbia University, Brown University, University of Alabama at Birmingham, University of North Carolina at Chapel Hill, MetroHealth, MetroHealth Medical Center, Case Western Reserve University, The University of Texas Medical Branch at Galveston, Memorial Hermann, The University of Texas Health Science Center at Houston
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1201304535, G1216570417, G124993864, Maternal Fetal Medicine Network: Data Coordinating Cent*, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, G2254024324, G2454580142, NICHD Maternal Fetal Medicine Units Network, G2594613454, NICHD Maternal-Fetal Medicine Units (MFMU) Network, G284963502, G29782494, Maternal-Fetal Medicine Units Network, G3226513114, G3409724790, Cooperative Multicenter Maternal Fetal Medicine Units Networks, G3786447104, G4027080872, G4238721334, G4640344014, G4657398957, G4821171242, G50908112, G6223460132, Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network (U10), G6657596466, Brown/WIH Eunice Kennedy Shriver NICHD MFM Units Network Site, Maternal Fetal Medicine Network, G715451306, NICHD Materal Fetal Medicine Units Network, Clinical and Translational Science Collaborative of Cleveland, G8675988754, Clinical and Translational Science Collaborative of Cleveland, UofU Maternal-Fetal Medicine Units (MFMU) Network: Clinical Centers, NICHD Maternal-Fetal Medicine Units (MFMU) Network: Data CoordinatingCenter, Brown University/Women & Infants Hospital of Rhode Island (WIH) Center Application for the Eunice Kennedy Shriver NICHD Maternal Fetal Medicine Units Network, Maternal Fetal Medicine Units Network - Northwestern Study Center, Case Western Reserve University Center of the NICHD MFMU Network, NICHD maternal fetal medicine units network, Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units (MFMU) Network (UG1), G922324195
OpenAlex ID: W4200179641