Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep
Year: 2021
Type: article
Abstract: Hypoxemia lowered fetal glucose oxidation rates, based on severity of hypoxemia, and increased lactate production. This was supported by tissue-specific metabolic responses that may result from increased norepinephrine and cortisol concentrations, which decrease pancreatic insulin secretion and insulin concentrations and decrease glucose utilization. This highlights the vulnerability of metabolic pathways in the fetus and demonstrates that constrained glucose oxidation may represent an early event in response to sustained hypoxemia and fetal growth restriction.
Institutions: University of Colorado Anschutz, University of Arizona
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Glucose metabolism in the fetal liver during hypoxia, G248384566, Nutrient coordination of pancreatic vasculature and B-cells, Physiological Ramifications of Chorionic Somatomammotropin Deficiency, UV-visible HPLC with PCX Pinnacle post column reaction module, Regulation of Fetal Skeletal Muscle Growth in IUGR, Training in Perinatal Medicine, Colorado Nutrition Obesity Research Center, Prevention of Placental Insufficiency Improves Beta-Cells Function, Insulin and nutrient actions in the FGR fetal liver
OpenAlex ID: W4200217323