Identification of Youthful Neurocognitive Trajectories in Adults Aging with HIV: A Latent Growth Mixture Model
Year: 2021
Type: article
Study design: Observational Study
Abstract: Despite the neurocognitive risks of aging with HIV, initial cross-sectional data suggest a subpopulation of older people with HIV (PWH) possess youthful neurocognition (NC) characteristic of SuperAgers (SA). Here we characterize longitudinal NC trajectories of older PWH and their convergent validity with baseline SA status, per established SuperAging criteria in PWH, and baseline biopsychosocial factors. Growth mixture modeling (GMM) identified longitudinal NC classes in 184 older (age ≥ 50-years) PWH with 1–5 years of follow-up. Classes were defined using ‘peak-age’ global T-scores, which compare performance to a normative sample of 25-year-olds. 3-classes were identified: Class 1Stable Elite (n = 31 [16.8%], high baseline peak-age T-scores with flat trajectory); Class 2Quadratic Average (n = 100 [54.3%], intermediate baseline peak-age T-scores with u-shaped trajectory); Class 3Quadratic Low (n = 53 [28.8%], low baseline peak-age T-scores with u-shaped trajectory). Baseline predictors of Class 1Stable Elite included SA status, younger age, higher cognitive and physiologic reserve, and fewer subjective cognitive difficulties. This GMM analysis supports the construct validity of SuperAging in older PWH through identification of a subgroup with longitudinally-stable, youthful neurocognition and robust biopsychosocial health.
Source: AIDS and Behavior
Authors: Rowan Saloner, Judith D. Lobo, Emily W. Paolillo, Laura M. Campbell, Scott L. Letendre, Mariana Cherner, Igor Grant, Robert K. Heaton, Ronald J. Ellis, Scott C. Roesch, David J. Moore, for the CHARTER Study Group, Igor Grant, Scott L. Letendre, Ronald J. Ellis, Thomas D. Marcotte, Donald Franklin, J. Allen McCutchan, Davey M. Smith, Robert K. Heaton, J. Hampton Atkinson, Matthew Dawson, Christine Fennema-Notestine, Michael J. Taylor, Rebecca Theilmann, Anthony C. Gamst, Clint Cushman, Ian Abramson, Florin Vaida, Ned Sacktor, Vincent Rogalski, Susan Morgello, David Simpson, Letty Mintz, J. Allen McCutchan, Ann Collier, Christina Marra, Sher Storey, Benjamin Gelman, Eleanor Head, David Clifford, Muhammad Al-Lozi, Mengesha Teshome
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,860
Awards: G1673230823, G1701606015, G25173860, CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER), G3350118538, G4623326455, G4738780424, G5209633835, Using Ecological Momentary Assessment to Improve Self-Reported Cognitive Functioning among Adults with Comorbid HIV/AIDS and Heavy Alcohol Use, G6391991693, Brain Morphology, Inflammation and Episodic Memory Profiles Among Persons Aging with HIV, G7110194617, G9000061284, G9000258202, Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN), HIV Neurobehavioral Research Center
OpenAlex ID: W4200228527