Mitochondrial ribosomal stress in lung diseases
Year: 2021
Type: review
Abstract: Mitochondria are involved in a variety of critical cellular functions, and their impairment drives cell injury. The mitochondrial ribosome (mitoribosome) is responsible for the protein synthesis of mitochondrial DNA-encoded genes. These proteins are involved in oxidative phosphorylation, respiration, and ATP production required in the cell. Mitoribosome components originate from both mitochondrial and nuclear genomes. Their dysfunction can be caused by impaired mitochondrial protein synthesis or mitoribosome misassembly, leading to a decline in mitochondrial translation. This decrease can trigger mitochondrial ribosomal stress and contribute to pulmonary cell injury, death, and diseases. This review focuses on the contribution of the impaired mitoribosome structural components and function to respiratory disease pathophysiology. We present recent findings in the fields of lung cancer, chronic obstructive pulmonary disease, interstitial lung disease, and asthma. We also include reports on the mitoribosome dysfunction in pulmonary hypertension, high-altitude pulmonary edema, and bacterial and viral infections. Studies of the mitoribosome alterations in respiratory diseases can lead to novel therapeutic targets.
Authors: Loukmane Karim, Beata Kosmider, Karim Bahmed
Institution: Temple University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Regulation of alveolar epithelial regeneration by T cells, EXOSOMES AS POTENTIAL THERAPEUTIC TARGETS IN GULF WAR ILLNESS., THE ROLE OF TRAF6 IN PRIMARY ALVEOLAR EPITHELIAL CELL INJURY, Alveolar epithelial cell dysfunction induced by flavored e-cigarette aerosols, Cigarette smoke influences alveolar type II cell-derived exosomes
OpenAlex ID: W4200233469