Work

Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics

Year: 2021

Type: article

Abstract: genes in all subjects who received doxycycline 100 mg or TMP/SMX, respectively. Last, analysis of metagenomic data revealed an increase of genes involved in gene mobilization, indicating stress responses of microbes to antibiotics. Collectively, these findings demonstrate direct, long-lasting effects of antibiotics on skin microbial communities, highlighting the skin microbiome as a site for the development and persistence of antibiotic resistance and the risks of overprescribing.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.abd8077

Authors: Jay-Hyun Jo, Catriona P. Harkins, Nicole H. Schwardt, Jessica A. Portillo, NISC Comparative Sequencing Program, Matthew D. Zimmerman, Claire L. Carter, Md Amir Hossen, Cody J. Peer, Eric C. Polley, Véronique Dartois, William D. Figg, Niki M. Moutsopoulos, Julia A. Segre, Heidi H. Kong

Institutions: National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Human Genome Research Institute, Hackensack Meridian Health, National Cancer Institute, Center for Cancer Research, National Institute of Dental and Craniofacial Research

Language: English

Topic: Dermatology and Skin Diseases

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health

Awards: G3661814986, A QTRAP 6500 LC-MS/MS System from SCIEX for high accuracy drug content analysis, G9000171835, G9000269818

OpenAlex ID: W4200235252

FWCI: 12.38

Cites: 75

Cited by: 116

Related to: 10