Work

Burning, but Not Dying: the Failure of Pyroptotic Cell Death in Hepatocytes

Year: 2021

Type: article

Abstract: Pyroptosis is a proinflammatory mode of regulated cell death that was first described in macrophages. Pyroptosis is triggered by microbial infection, as well as by a variety of pathogen-associated molecular patterns, such as bacterial lipopolysaccharide (LPS) and nucleic acids, and danger-associated molecular patterns, such as the DNA binding protein high mobility group box-1, oxidized lipoproteins, and host-derived stress signals.1 Pathogen-associated molecular patterns and danger-associated molecular patterns are sensed by cell-surface pattern recognition receptors, which associate intracellularly to form multiprotein complexes termed inflammasomes, which promote the activation of proinflammatory caspase-1 (canonical pathway), and/or caspase-4/-5 (in human beings) and caspase-11 (in mice) (noncanonical pathway).

Source: Cellular and Molecular Gastroenterology and Hepatology

DOI: 10.1016/j.jcmgh.2021.12.006

Authors: Maria Eugenia Guicciardi, Gregory J. Gores

Institution: Mayo Clinic

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500